Researchers from Adamo Foods and the University of Nottingham investigated how nutritional manipulation of fermentation media, specifically the addition of iron (Fe III) and Vitamin B12, impacts the yield, texture, and nutritional profile of fungal mycelium grown for alternative meat applications. Using the INFORS HT Techfors-S pilot bioreactor, the team scaled up production from shake flasks and observed significant increases in bioaccumulation of iron and B12, with up to 97% terephthalic acid yield sustained across multiple cycles. Sensory testing of biomass processed into steaks also revealed changes in texture and flavor, highlighting the importance of bioreactor-based media optimization for developing high-quality, reproducible mycelium-based products.

In this study, researchers have optimized the purification of IL-2 no-alpha mutein using copper-catalyzed air oxidation. This process, using the INFORS HT Techfors pilot bioreactor, improves the homogeneity and biological activity of the IL-2 agonist, which shows promise in Phase I/II trials for cancer treatment.

Feeding strategy is one of the most influential variables in any bioprocess. Whether you’re working with bacterial, yeast, fungal, or mammalian cell cultures, how you supply nutrients affects everything from growth rates and yields to oxygen demand and product quality. The choice between batch, fed-batch, and continuous culture depends on your organism, application, and production goals. Fortunately, modern bioreactor systems like those from INFORS HT make it easy to implement any of these strategies at lab or pilot scale.

Discover how INFORS HT bioreactors and services have supported bioprocess education and research at Universiti Sains Malaysia (USM). Joo Shun TAN (陈裕声), Associate Professor, shares insights on leveraging Minifors, Multifors, and Techfors bioreactors to enhance teaching, research, and scale-up processes.