Autotrophic adaptive laboratory evolution of the acetogen Clostridium autoethanogenum delivers the gas-fermenting strain LAbrini with superior growth, products, and robustness

Researchers at the University of Tartu, Institute of Bioengineering used adaptive laboratory evolution (ALE) to evolve Clostridium autoethanogenum into a faster-growing, yeast extract-free strain named LAbrini. This strain demonstrates improved robustness and performance in continuous bioreactor cultures, offering new potential for sustainable production of renewable chemicals and fuels.