Expression of the human molecular chaperone domain Bri2 BRICHOS on a gram per liter scale with an E. coli fed-batch culture

The goal of this research. conduced at Karolinska Institutet in Stockholm, Sweden, was to improve the productivity of human Bri2 BRICHOS domain production. The human Bri2 BRICHOS domain inhibits amyloid formation and toxicity and could be used as a therapeutic agent against amyloid diseases, such as alzheimers disease.