Product
Researchers at the Helmholtz Centre for Environmental Research, in Germany, have developed an in vitro model to investigate how environmental chemicals, such as bisphenols (BPX) and PFAS mixtures, affect the interactions between the microbiome and immune system. Using the Multifors bench-top bioreactor, they demonstrated that chronic chemical exposure can alter immune cell activation without affecting microbial community structure.
Researchers at the Helmholtz Centre for Environmental Research, in Germany, have developed an in vitro model to investigate how environmental chemicals, such as bisphenols (BPX) and PFAS mixtures, affect the interactions between the microbiome and immune system. Using the Multifors bench-top bioreactor, they demonstrated that chronic chemical exposure can alter immune cell activation without affecting microbial community structure.
Researchers from the University of São Paulo have developed an innovative two-stage anaerobic digestion process that enhances methane production from sugarcane vinasse. Their approach, which integrates a fermentative-sulfidogenic stage, boosts biogas quality, lowers costs, and eliminates the need for chemical additives. This promising solution could revolutionize bioenergy recovery in sugarcane biorefineries.
Researchers from the University of Wisconsin-Madison utilized an optimized Multifors bench-top bioreactor system to significantly enhance the production of 2-pyrone-4,6-dicarboxylic acid (PDC) from aqueous aromatic streams using Novosphingobium aromaticivorans. Their findings demonstrate how membrane separation and pH control improvements boost PDC yields, advancing the production of biochemicals from lignocellulosic biomass for polymer-based materials.
Researchers from the School of Natural Sciences at TU Munich utilized the Minifors bench-top bioreactor to support their innovative experiment on cell-free gene expression in bioprinted fluidic networks. This study highlights how integrating cell-free protein synthesis into vascularized hydrogels enables dynamic molecular control, providing valuable insights for creating synthetic biomaterials that mimic biological functions.
Researchers at the University of Delaware used the INFORS HT Multitron incubator shaker to evaluate biolayer interferometry (BLI) for fast, high-throughput AAV capsid titer measurement. The study highlights the accuracy of AAVX-BLI across multiple rAAV serotypes, making it a strong alternative to ELISA. Applied in transfection optimization and AAV purification, this method offers valuable insights for improving rAAV production processes.
Researchers at Adimab, LLC isolated 188 monoclonal antibodies against Crimean-Congo hemorrhagic fever virus (CCHFV) GP38 from human survivors. While non-neutralizing, these antibodies target 11 overlapping sites and demonstrate protective efficacy in rodent models. This study provides valuable insights into CCHFV viral glycoprotein and could aid the development of antibody therapeutics for this lethal virus.
Researchers from the Institute of Bioprocess Engineering and Pharmaceutical Technology at the University of Applied Sciences Mittelhessen have made strides in chemoorganotrophic electrofermentation using Cupriavidus necator. By experimenting with different redox mediators, they identified ferricyanide as a key player in enhancing anodic respiration. With the INFORS HT Multitron providing precise environmental control, the team achieved remarkable current densities, offering a promising solution to the challenges of oxygen-driven fermentation systems.
Researchers at Université Paris-Saclay have developed a mathematical model that accurately predicts pH and metabolite concentrations during the microbial production of 3-hydroxypropionic acid using acetic acid bacteria. Using the INFORS HT Labfors bioreactor, the study focused on the bioconversion of 1,3-propanediol, taking into account the buffering capacity of the biological medium. Their model not only provided precise predictions of microbial growth and acid concentration but also serves as a critical tool for optimizing bioprocesses, particularly in scenarios with free pH dynamics. This work lays the foundation for future advancements in the production and in-situ extraction of organic acids.
Researchers from the Department of Parasitology-Mycology at Institut Pasteur de Côte d'Ivoire are exploring new solutions for diagnosing human cysticercosis in remote areas. Their study tested a set of recombinant antigens for use in ELISA assays as a low-cost alternative to neuroimaging. While some challenges remain in optimizing sensitivity, the results show great promise, particularly in regions with limited medical resources. These antigens could provide a crucial screening tool for detecting neurocysticercosis, especially in patients with epilepsy, helping those in remote areas access better diagnosis and care.
Researchers from Technische Universität Berlin have made significant progress in understanding the regulatory network behind polyhydroxyalkanoate (PHA) metabolism in Ralstonia eutropha. Their study, using the Multitron Standard incubator shaker, confirmed a key interaction involving transcription factor H16_B1672 and identified several other regulators that impact PHA synthesis. Despite challenges in fully characterizing all transcription factors, this research lays the groundwork for optimizing PHA production for industrial use, advancing sustainable bioplastic solutions.
Researchers from the University of São Paulo have developed an innovative two-stage anaerobic digestion process that enhances methane production from sugarcane vinasse. Their approach, which integrates a fermentative-sulfidogenic stage, boosts biogas quality, lowers costs, and eliminates the need for chemical additives. This promising solution could revolutionize bioenergy recovery in sugarcane biorefineries.
Researchers from the University of Wisconsin-Madison utilized an optimized Multifors bench-top bioreactor system to significantly enhance the production of 2-pyrone-4,6-dicarboxylic acid (PDC) from aqueous aromatic streams using Novosphingobium aromaticivorans. Their findings demonstrate how membrane separation and pH control improvements boost PDC yields, advancing the production of biochemicals from lignocellulosic biomass for polymer-based materials.
Researchers from the School of Natural Sciences at TU Munich utilized the Minifors bench-top bioreactor to support their innovative experiment on cell-free gene expression in bioprinted fluidic networks. This study highlights how integrating cell-free protein synthesis into vascularized hydrogels enables dynamic molecular control, providing valuable insights for creating synthetic biomaterials that mimic biological functions.
Researchers at the University of Delaware used the INFORS HT Multitron incubator shaker to evaluate biolayer interferometry (BLI) for fast, high-throughput AAV capsid titer measurement. The study highlights the accuracy of AAVX-BLI across multiple rAAV serotypes, making it a strong alternative to ELISA. Applied in transfection optimization and AAV purification, this method offers valuable insights for improving rAAV production processes.
Researchers at Adimab, LLC isolated 188 monoclonal antibodies against Crimean-Congo hemorrhagic fever virus (CCHFV) GP38 from human survivors. While non-neutralizing, these antibodies target 11 overlapping sites and demonstrate protective efficacy in rodent models. This study provides valuable insights into CCHFV viral glycoprotein and could aid the development of antibody therapeutics for this lethal virus.
Researchers from the Institute of Bioprocess Engineering and Pharmaceutical Technology at the University of Applied Sciences Mittelhessen have made strides in chemoorganotrophic electrofermentation using Cupriavidus necator. By experimenting with different redox mediators, they identified ferricyanide as a key player in enhancing anodic respiration. With the INFORS HT Multitron providing precise environmental control, the team achieved remarkable current densities, offering a promising solution to the challenges of oxygen-driven fermentation systems.
Researchers at Université Paris-Saclay have developed a mathematical model that accurately predicts pH and metabolite concentrations during the microbial production of 3-hydroxypropionic acid using acetic acid bacteria. Using the INFORS HT Labfors bioreactor, the study focused on the bioconversion of 1,3-propanediol, taking into account the buffering capacity of the biological medium. Their model not only provided precise predictions of microbial growth and acid concentration but also serves as a critical tool for optimizing bioprocesses, particularly in scenarios with free pH dynamics. This work lays the foundation for future advancements in the production and in-situ extraction of organic acids.
Researchers from the Department of Parasitology-Mycology at Institut Pasteur de Côte d'Ivoire are exploring new solutions for diagnosing human cysticercosis in remote areas. Their study tested a set of recombinant antigens for use in ELISA assays as a low-cost alternative to neuroimaging. While some challenges remain in optimizing sensitivity, the results show great promise, particularly in regions with limited medical resources. These antigens could provide a crucial screening tool for detecting neurocysticercosis, especially in patients with epilepsy, helping those in remote areas access better diagnosis and care.
Researchers from Technische Universität Berlin have made significant progress in understanding the regulatory network behind polyhydroxyalkanoate (PHA) metabolism in Ralstonia eutropha. Their study, using the Multitron Standard incubator shaker, confirmed a key interaction involving transcription factor H16_B1672 and identified several other regulators that impact PHA synthesis. Despite challenges in fully characterizing all transcription factors, this research lays the groundwork for optimizing PHA production for industrial use, advancing sustainable bioplastic solutions.