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16 abr 2025
22 min read
The impact of annealing methods on the encapsulating structure and storage-stability of freeze-dried pellets of probiotic bacteria

At Lund University, Division of Food and Pharma, researchers studied the role of annealing in the freeze-drying of probiotic bacteria. Using the INFORS HT Multifors bioreactor and eve software, they controlled the fermentation of Limosilactobacillus reuteri to produce consistent cell cultures for downstream drying. Their results show that increased annealing time leads to thicker encapsulating structures and enhanced storage stability, providing a clearer path to developing more robust probiotic products.

16 abr 202522 min read
The impact of annealing methods on the encapsulating structure and storage-stability of freeze-dried pellets of probiotic bacteria

At Lund University, Division of Food and Pharma, researchers studied the role of annealing in the freeze-drying of probiotic bacteria. Using the INFORS HT Multifors bioreactor and eve software, they controlled the fermentation of Limosilactobacillus reuteri to produce consistent cell cultures for downstream drying. Their results show that increased annealing time leads to thicker encapsulating structures and enhanced storage stability, providing a clearer path to developing more robust probiotic products.

16 abr 202542 min read
Bioethanol production from organosolv treated beech wood chips obtained at pilot scale

At the University of Boras in Sweden, researchers have scaled up second-generation bioethanol production from beech wood chips using an acetone-based organosolv fractionation process. With the help of the INFORS HT Multifors bench-top bioreactor, they confirmed high fermentation efficiency at the 10-L scale, reaching ethanol yields of up to 95% from glucose-rich C6 streams. This study illustrates how optimized biomass pre-treatment and fermentation workflows can drive more efficient and scalable biofuel production.

05 mar 202534 min read
Recombinant laccase biosynthesis for efficient polydopamine coating

In a study from the University of Aveiro, researchers leveraged the INFORS HT Minifors bench-top bioreactor to optimize recombinant laccase production in Komagataella phaffii. By fine-tuning cultivation conditions, they scaled laccase production and demonstrated its stability and effectiveness as a biocatalyst. Notably, this laccase was used to assist dopamine polymerization, achieving an innovative polydopamine coating on filter paper, an exciting advance in enzyme applications for material science.

05 mar 202545 min read
Methane production from sugarcane vinasse: The alkalinizing potential of fermentative-sulfidogenic processes in two-stage anaerobic digestion

Researchers from the University of São Paulo have developed an innovative two-stage anaerobic digestion process that enhances methane production from sugarcane vinasse. Their approach, which integrates a fermentative-sulfidogenic stage, boosts biogas quality, lowers costs, and eliminates the need for chemical additives. This promising solution could revolutionize bioenergy recovery in sugarcane biorefineries.

05 mar 202542 min read
Chemoorganotrophic electrofermentation by Cupriavidus necator using redox mediators

Researchers from the Institute of Bioprocess Engineering and Pharmaceutical Technology at the University of Applied Sciences Mittelhessen have made strides in chemoorganotrophic electrofermentation using Cupriavidus necator. By experimenting with different redox mediators, they identified ferricyanide as a key player in enhancing anodic respiration. With the INFORS HT Multitron providing precise environmental control, the team achieved remarkable current densities, offering a promising solution to the challenges of oxygen-driven fermentation systems.

05 mar 202546 min read
Studies of polyol production by the yeast Yarrowia lipolytica growing on crude glycerol under stressful conditions

Researchers from the University of Athens have successfully harnessed crude glycerol, a biodiesel by-product, as a substrate for producing valuable compounds like polyols and yeast biomass. Their study highlights the adaptability of wild-type Yarrowia lipolytica strains under low pH, low temperature, and non-aseptic conditions, offering a sustainable approach to bio-based production.

05 mar 202553 min read
Autotrophic adaptive laboratory evolution of the acetogen Clostridium autoethanogenum delivers the gas-fermenting strain LAbrini with superior growth, products, and robustness

Researchers at the University of Tartu, Institute of Bioengineering used adaptive laboratory evolution (ALE) to evolve Clostridium autoethanogenum into a faster-growing, yeast extract-free strain named LAbrini. This strain demonstrates improved robustness and performance in continuous bioreactor cultures, offering new potential for sustainable production of renewable chemicals and fuels.

05 mar 202530 min read
Clostridium autoethanogenum alters cofactor synthesis, redox metabolism, and lysine-acetylation in response to elevated H2:CO feedstock ratios for enhancing carbon capture efficiency

A study conducted by LanzaTech, published in Biotechnology for Biofuels, explores how Clostridium autoethanogenum (an acetogenic bacterium) adapts to various hydrogen ratios in its feedstock. The focus of this study is to enhance carbon capture efficiency with a spotlight on CO₂ conversion. This research unveils the metabolic adaptations of C. autoethanogenum and paves the way for innovative bioengineering strategies to maximize CO₂ conversion in industrial applications.

05 mar 202535 min read
Robust, fully quantifiable and scalable bioprocess utilizing spent sulfite liquor with Corynebacterium glutamicum

This study, published on ScienceDirect, aimed to revolutionize bioproduction by developing a cost-effective, robust, and scalable platform using a novel approach with C. glutamicum and UF-SSL. This research eliminates costly media additives and energy-intensive detoxification steps, paving the way for more efficient and sustainable industrial ethanol production.

17 fev 202553 min read
Heritable non-genetic phenotypes are enriched for stress responses as a form of bet hedging

Researchers from the University of Delaware, Departments of Chemical and Biomolecular Engineering and Electrical and Computer Engineering have made strides in enhancing the resilience of Chinese hamster ovary (CHO) cells used in biopharmaceutical production. By employing the INFORS HT Multitron incubator shaker, they exposed CHO cells to stress conditions commonly encountered during manufacturing, such as elevated levels of ammonia, lactate, and osmolality. Through comprehensive transcriptomic analysis, the team identified 199 genes exhibiting bistable expression, with seven emerging as prime candidates for engineering stress-resistant cell lines. This research holds promise for optimizing cell health and boosting productivity in large-scale bioreactor operations.

16 abr 202542 min read
Bioethanol production from organosolv treated beech wood chips obtained at pilot scale

At the University of Boras in Sweden, researchers have scaled up second-generation bioethanol production from beech wood chips using an acetone-based organosolv fractionation process. With the help of the INFORS HT Multifors bench-top bioreactor, they confirmed high fermentation efficiency at the 10-L scale, reaching ethanol yields of up to 95% from glucose-rich C6 streams. This study illustrates how optimized biomass pre-treatment and fermentation workflows can drive more efficient and scalable biofuel production.

05 mar 202534 min read
Recombinant laccase biosynthesis for efficient polydopamine coating

In a study from the University of Aveiro, researchers leveraged the INFORS HT Minifors bench-top bioreactor to optimize recombinant laccase production in Komagataella phaffii. By fine-tuning cultivation conditions, they scaled laccase production and demonstrated its stability and effectiveness as a biocatalyst. Notably, this laccase was used to assist dopamine polymerization, achieving an innovative polydopamine coating on filter paper, an exciting advance in enzyme applications for material science.

05 mar 202545 min read
Methane production from sugarcane vinasse: The alkalinizing potential of fermentative-sulfidogenic processes in two-stage anaerobic digestion

Researchers from the University of São Paulo have developed an innovative two-stage anaerobic digestion process that enhances methane production from sugarcane vinasse. Their approach, which integrates a fermentative-sulfidogenic stage, boosts biogas quality, lowers costs, and eliminates the need for chemical additives. This promising solution could revolutionize bioenergy recovery in sugarcane biorefineries.

05 mar 202542 min read
Chemoorganotrophic electrofermentation by Cupriavidus necator using redox mediators

Researchers from the Institute of Bioprocess Engineering and Pharmaceutical Technology at the University of Applied Sciences Mittelhessen have made strides in chemoorganotrophic electrofermentation using Cupriavidus necator. By experimenting with different redox mediators, they identified ferricyanide as a key player in enhancing anodic respiration. With the INFORS HT Multitron providing precise environmental control, the team achieved remarkable current densities, offering a promising solution to the challenges of oxygen-driven fermentation systems.

05 mar 202546 min read
Studies of polyol production by the yeast Yarrowia lipolytica growing on crude glycerol under stressful conditions

Researchers from the University of Athens have successfully harnessed crude glycerol, a biodiesel by-product, as a substrate for producing valuable compounds like polyols and yeast biomass. Their study highlights the adaptability of wild-type Yarrowia lipolytica strains under low pH, low temperature, and non-aseptic conditions, offering a sustainable approach to bio-based production.

05 mar 202553 min read
Autotrophic adaptive laboratory evolution of the acetogen Clostridium autoethanogenum delivers the gas-fermenting strain LAbrini with superior growth, products, and robustness

Researchers at the University of Tartu, Institute of Bioengineering used adaptive laboratory evolution (ALE) to evolve Clostridium autoethanogenum into a faster-growing, yeast extract-free strain named LAbrini. This strain demonstrates improved robustness and performance in continuous bioreactor cultures, offering new potential for sustainable production of renewable chemicals and fuels.

05 mar 202530 min read
Clostridium autoethanogenum alters cofactor synthesis, redox metabolism, and lysine-acetylation in response to elevated H2:CO feedstock ratios for enhancing carbon capture efficiency

A study conducted by LanzaTech, published in Biotechnology for Biofuels, explores how Clostridium autoethanogenum (an acetogenic bacterium) adapts to various hydrogen ratios in its feedstock. The focus of this study is to enhance carbon capture efficiency with a spotlight on CO₂ conversion. This research unveils the metabolic adaptations of C. autoethanogenum and paves the way for innovative bioengineering strategies to maximize CO₂ conversion in industrial applications.

05 mar 202535 min read
Robust, fully quantifiable and scalable bioprocess utilizing spent sulfite liquor with Corynebacterium glutamicum

This study, published on ScienceDirect, aimed to revolutionize bioproduction by developing a cost-effective, robust, and scalable platform using a novel approach with C. glutamicum and UF-SSL. This research eliminates costly media additives and energy-intensive detoxification steps, paving the way for more efficient and sustainable industrial ethanol production.

17 fev 202553 min read
Heritable non-genetic phenotypes are enriched for stress responses as a form of bet hedging

Researchers from the University of Delaware, Departments of Chemical and Biomolecular Engineering and Electrical and Computer Engineering have made strides in enhancing the resilience of Chinese hamster ovary (CHO) cells used in biopharmaceutical production. By employing the INFORS HT Multitron incubator shaker, they exposed CHO cells to stress conditions commonly encountered during manufacturing, such as elevated levels of ammonia, lactate, and osmolality. Through comprehensive transcriptomic analysis, the team identified 199 genes exhibiting bistable expression, with seven emerging as prime candidates for engineering stress-resistant cell lines. This research holds promise for optimizing cell health and boosting productivity in large-scale bioreactor operations.

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