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02 Dec 2024
40 min read
Chemical mixture effects on the simplified human intestinal microbiota: Assessing xenobiotics at environmentally realistic concentrations

Researchers at Helmholtz-Centre for Environmental Research UFZ GmbH, Leipzig, explored the effects of xenobiotics on gut microbiota using the Multifors bench-top bioreactor. Their findings highlight the impact of environmental contaminants like PFAS and BPX on microbial communities and metabolic pathways, emphasizing the need to consider these interactions for public health.

02 Dec 202440 min read
Chemical mixture effects on the simplified human intestinal microbiota: Assessing xenobiotics at environmentally realistic concentrations

Researchers at Helmholtz-Centre for Environmental Research UFZ GmbH, Leipzig, explored the effects of xenobiotics on gut microbiota using the Multifors bench-top bioreactor. Their findings highlight the impact of environmental contaminants like PFAS and BPX on microbial communities and metabolic pathways, emphasizing the need to consider these interactions for public health.

25 Nov 202452 min read
Metabolic bottlenecks of Pseudomonas taiwanensis VLB120 during growth on d-xylose via the Weimberg pathway

Researchers at TU Dortmund University have uncovered metabolic bottlenecks in Pseudomonas taiwanensis during growth on d-xylose, using the INFORS HT Multitron Standard incubator shaker. Their findings offer new insights into optimizing the Weimberg pathway for bioprocesses on renewable feedstocks, advancing strain development and bioproduction.

25 Nov 202436 min read
Characterization of bacterial cellulose produced by the KomEt strain isolated from a kombucha SCOBY

Researchers at Université de Sherbrooke have successfully characterized bacterial cellulose (BC) produced from a novel strain isolated from a kombucha SCOBY. Using the Minitron incubator shaker and an INFORS HT bioreactor, they evaluated the mechanical, thermal, and chemical properties of BC, revealing its potential for applications in biomedical, textile, and cosmetic industries.

25 Nov 202449 min read
Achieving high productivity of 2-pyrone-4,6-dicarboxylic acid from aqueous aromatic streams with novosphingobium aromaticivorans

Researchers from the University of Wisconsin-Madison utilized an optimized Multifors bench-top bioreactor system to significantly enhance the production of 2-pyrone-4,6-dicarboxylic acid (PDC) from aqueous aromatic streams using Novosphingobium aromaticivorans. Their findings demonstrate how membrane separation and pH control improvements boost PDC yields, advancing the production of biochemicals from lignocellulosic biomass for polymer-based materials.

25 Nov 202438 min read
Cell-free gene expression in bioprinted fluidic networks

Researchers from the School of Natural Sciences at TU Munich utilized the Minifors bench-top bioreactor to support their innovative experiment on cell-free gene expression in bioprinted fluidic networks. This study highlights how integrating cell-free protein synthesis into vascularized hydrogels enables dynamic molecular control, providing valuable insights for creating synthetic biomaterials that mimic biological functions.

25 Nov 202442 min read
Chemoorganotrophic electrofermentation by Cupriavidus necator using redox mediators

Researchers from the Institute of Bioprocess Engineering and Pharmaceutical Technology at the University of Applied Sciences Mittelhessen have made strides in chemoorganotrophic electrofermentation using Cupriavidus necator. By experimenting with different redox mediators, they identified ferricyanide as a key player in enhancing anodic respiration. With the INFORS HT Multitron providing precise environmental control, the team achieved remarkable current densities, offering a promising solution to the challenges of oxygen-driven fermentation systems.

25 Nov 202433 min read
Production and evaluation of a new set of recombinant antigens for the serological diagnosis of human cysticercosis

Researchers from the Department of Parasitology-Mycology at Institut Pasteur de Côte d'Ivoire are exploring new solutions for diagnosing human cysticercosis in remote areas. Their study tested a set of recombinant antigens for use in ELISA assays as a low-cost alternative to neuroimaging. While some challenges remain in optimizing sensitivity, the results show great promise, particularly in regions with limited medical resources. These antigens could provide a crucial screening tool for detecting neurocysticercosis, especially in patients with epilepsy, helping those in remote areas access better diagnosis and care.

25 Nov 202460 min read
Crimean-Congo hemorrhagic fever survivors elicit protective non-neutralizing antibodies that target 11 overlapping regions on glycoprotein GP38

Researchers at Adimab, LLC isolated 188 monoclonal antibodies against Crimean-Congo hemorrhagic fever virus (CCHFV) GP38 from human survivors. While non-neutralizing, these antibodies target 11 overlapping sites and demonstrate protective efficacy in rodent models. This study provides valuable insights into CCHFV viral glycoprotein and could aid the development of antibody therapeutics for this lethal virus.

25 Nov 202440 min read
Elucidating regulation of polyhydroxyalkanoate metabolism in Ralstonia eutropha

Researchers from Technische Universität Berlin have made significant progress in understanding the regulatory network behind polyhydroxyalkanoate (PHA) metabolism in Ralstonia eutropha. Their study, using the Multitron Standard incubator shaker, confirmed a key interaction involving transcription factor H16_B1672 and identified several other regulators that impact PHA synthesis. Despite challenges in fully characterizing all transcription factors, this research lays the groundwork for optimizing PHA production for industrial use, advancing sustainable bioplastic solutions.

25 Nov 202436 min read
Chlorella vulgaris cold preservation as a means to stabilize biomass for bioreactor inoculation: A six-month study

Researchers at Université Paris-Saclay explored efficient methods to preserve Chlorella vulgaris cells over six months with minimal maintenance. Their findings demonstrated that storing cells at 4C provided a stable, repeatable inoculum while reducing the need for frequent subculturing, compared to traditional maintenance methods. This approach allows for consistent experimental results and simplifies cell preservation in biotechnological applications. The research emphasizes the potential of low-temperature storage to streamline lab processes and reduce variability in microalgal studies.

25 Nov 202452 min read
Metabolic bottlenecks of Pseudomonas taiwanensis VLB120 during growth on d-xylose via the Weimberg pathway

Researchers at TU Dortmund University have uncovered metabolic bottlenecks in Pseudomonas taiwanensis during growth on d-xylose, using the INFORS HT Multitron Standard incubator shaker. Their findings offer new insights into optimizing the Weimberg pathway for bioprocesses on renewable feedstocks, advancing strain development and bioproduction.

25 Nov 202436 min read
Characterization of bacterial cellulose produced by the KomEt strain isolated from a kombucha SCOBY

Researchers at Université de Sherbrooke have successfully characterized bacterial cellulose (BC) produced from a novel strain isolated from a kombucha SCOBY. Using the Minitron incubator shaker and an INFORS HT bioreactor, they evaluated the mechanical, thermal, and chemical properties of BC, revealing its potential for applications in biomedical, textile, and cosmetic industries.

25 Nov 202449 min read
Achieving high productivity of 2-pyrone-4,6-dicarboxylic acid from aqueous aromatic streams with novosphingobium aromaticivorans

Researchers from the University of Wisconsin-Madison utilized an optimized Multifors bench-top bioreactor system to significantly enhance the production of 2-pyrone-4,6-dicarboxylic acid (PDC) from aqueous aromatic streams using Novosphingobium aromaticivorans. Their findings demonstrate how membrane separation and pH control improvements boost PDC yields, advancing the production of biochemicals from lignocellulosic biomass for polymer-based materials.

25 Nov 202438 min read
Cell-free gene expression in bioprinted fluidic networks

Researchers from the School of Natural Sciences at TU Munich utilized the Minifors bench-top bioreactor to support their innovative experiment on cell-free gene expression in bioprinted fluidic networks. This study highlights how integrating cell-free protein synthesis into vascularized hydrogels enables dynamic molecular control, providing valuable insights for creating synthetic biomaterials that mimic biological functions.

25 Nov 202442 min read
Chemoorganotrophic electrofermentation by Cupriavidus necator using redox mediators

Researchers from the Institute of Bioprocess Engineering and Pharmaceutical Technology at the University of Applied Sciences Mittelhessen have made strides in chemoorganotrophic electrofermentation using Cupriavidus necator. By experimenting with different redox mediators, they identified ferricyanide as a key player in enhancing anodic respiration. With the INFORS HT Multitron providing precise environmental control, the team achieved remarkable current densities, offering a promising solution to the challenges of oxygen-driven fermentation systems.

25 Nov 202433 min read
Production and evaluation of a new set of recombinant antigens for the serological diagnosis of human cysticercosis

Researchers from the Department of Parasitology-Mycology at Institut Pasteur de Côte d'Ivoire are exploring new solutions for diagnosing human cysticercosis in remote areas. Their study tested a set of recombinant antigens for use in ELISA assays as a low-cost alternative to neuroimaging. While some challenges remain in optimizing sensitivity, the results show great promise, particularly in regions with limited medical resources. These antigens could provide a crucial screening tool for detecting neurocysticercosis, especially in patients with epilepsy, helping those in remote areas access better diagnosis and care.

25 Nov 202460 min read
Crimean-Congo hemorrhagic fever survivors elicit protective non-neutralizing antibodies that target 11 overlapping regions on glycoprotein GP38

Researchers at Adimab, LLC isolated 188 monoclonal antibodies against Crimean-Congo hemorrhagic fever virus (CCHFV) GP38 from human survivors. While non-neutralizing, these antibodies target 11 overlapping sites and demonstrate protective efficacy in rodent models. This study provides valuable insights into CCHFV viral glycoprotein and could aid the development of antibody therapeutics for this lethal virus.

25 Nov 202440 min read
Elucidating regulation of polyhydroxyalkanoate metabolism in Ralstonia eutropha

Researchers from Technische Universität Berlin have made significant progress in understanding the regulatory network behind polyhydroxyalkanoate (PHA) metabolism in Ralstonia eutropha. Their study, using the Multitron Standard incubator shaker, confirmed a key interaction involving transcription factor H16_B1672 and identified several other regulators that impact PHA synthesis. Despite challenges in fully characterizing all transcription factors, this research lays the groundwork for optimizing PHA production for industrial use, advancing sustainable bioplastic solutions.

25 Nov 202436 min read
Chlorella vulgaris cold preservation as a means to stabilize biomass for bioreactor inoculation: A six-month study

Researchers at Université Paris-Saclay explored efficient methods to preserve Chlorella vulgaris cells over six months with minimal maintenance. Their findings demonstrated that storing cells at 4C provided a stable, repeatable inoculum while reducing the need for frequent subculturing, compared to traditional maintenance methods. This approach allows for consistent experimental results and simplifies cell preservation in biotechnological applications. The research emphasizes the potential of low-temperature storage to streamline lab processes and reduce variability in microalgal studies.

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