Publicaciones

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13 sep. 202440 min read
Diamide-based screening method for the isolation of improved oxidative stress tolerance phenotypes in Bacillus mutant libraries

This study, on ASM Journals, discusses promising methods to selectively identify phenotypes in B. subtilis with improved tolerance toward oxidative and disulfide-associated stress. The Multitron incubator shaker was used to quickly screen large libraries of transposon mutants for those bacteria that show enhanced tolerance towards oxidative stress.

13 sep. 202410 min read
Rapid and simultaneous screening of pathway designs and chassis organisms, applied to engineered living materials

This scientific research paper on ScienceDirect highlights the Multitron incubator shaker as a tool for enhancing productivity of simultaneous screening of genetic designs and chassis during the build step of metabolic engineering.

13 sep. 202435 min read
Robust, fully quantifiable and scalable bioprocess utilizing spent sulfite liquor with Corynebacterium glutamicum

This study, published on ScienceDirect, aimed to revolutionize bioproduction by developing a cost-effective, robust, and scalable platform using a novel approach with C. glutamicum and UF-SSL. This research eliminates costly media additives and energy-intensive detoxification steps, paving the way for more efficient and sustainable industrial ethanol production.

13 sep. 202430 min read
Expression of the human molecular chaperone domain Bri2 BRICHOS on a gram per liter scale with an E. coli fed-batch culture

The goal of this research. conduced at Karolinska Institutet in Stockholm, Sweden, was to improve the productivity of human Bri2 BRICHOS domain production. The human Bri2 BRICHOS domain inhibits amyloid formation and toxicity and could be used as a therapeutic agent against amyloid diseases, such as alzheimers disease. 

13 sep. 202432 min read
Metabolic control analysis enabled the improvement of the L-cysteine production process with Escherichia coli

This research that was conducted at the Technical University of Munich, where scientists utilized an INFORS HT Techfors pilot bioreactor to evaluate and refine the expression of L-cysteine (amino acid widely used in pharmaceutical, food, feed, and cosmetic industries) synthases, achieving a productivity improvement of ~70%.

13 sep. 202435 min read
Non-inhibitory levels of oxygen during cultivation increase freeze-drying stress tolerance in Limosilactobacillus reuteri DSM 17938

This research was done by Nikhil Seshagiri Rao, Ph.D. and a team of scientists at Lund University in Sweden, published in the journal, Frontiers in Microbiology, where they utilized the INFORS HT Minifors bioreactor system with eve® bioprocess platform software to evaluate the effects of oxygen during cultivation on freeze-drying stress tolerance.

13 sep. 202426 min read
Development of a unique rapid test to detect antibodies directed against an extended RBD of SARS-CoV-2 spike protein

Researchers at University of Applied Sciences and Arts Northwestern Switzerland FHNW worked to develop a rapid test that measures patient immune protection from SARS-CoV-2, resulting from prior infection or vaccination. Their work utilized INFORS HT's Techfors-S pilot bioreactor.

13 sep. 202422 min read
Chemometric tool to monitor and predict cell viability in filamentous fungi bioprocesses using chromatogram fingerprints

Researchers at Technische Universität Wien sought to develop simplified and improved methods for monitoring and predicting cell viability in bioprocesses with complex expression systems, such as filamentous fungi. Their work utilized the INFORS HT Techfors-S pilot bioreactor.

13 sep. 202430 min read
Clostridium autoethanogenum alters cofactor synthesis, redox metabolism, and lysine-acetylation in response to elevated H2:CO feedstock ratios for enhancing carbon capture efficiency

A study conducted by LanzaTech, published in Biotechnology for Biofuels, explores how Clostridium autoethanogenum (an acetogenic bacterium) adapts to various hydrogen ratios in its feedstock. The focus of this study is to enhance carbon capture efficiency with a spotlight on CO₂ conversion. This research unveils the metabolic adaptations of C. autoethanogenum and paves the way for innovative bioengineering strategies to maximize CO₂ conversion in industrial applications.

13 sep. 202430 min read
Expression and characterization of recombinant IL-1Ra in Aspergillus oryzae as a system

In a new study, published on Springer Link, researchers produced a more stable and cost-effective interleukin-1 receptor antagonist (IL-1Ra) using Aspergillus oryzae. This alternative to E. coli-expressed IL-1Ra offers improved stability and bioactivity, making it a promising option for industrial-scale production. Explore the full findings and implications for therapeutic manufacturing.

13 sep. 202410 min read
Rapid and simultaneous screening of pathway designs and chassis organisms, applied to engineered living materials

This scientific research paper on ScienceDirect highlights the Multitron incubator shaker as a tool for enhancing productivity of simultaneous screening of genetic designs and chassis during the build step of metabolic engineering.

13 sep. 202435 min read
Robust, fully quantifiable and scalable bioprocess utilizing spent sulfite liquor with Corynebacterium glutamicum

This study, published on ScienceDirect, aimed to revolutionize bioproduction by developing a cost-effective, robust, and scalable platform using a novel approach with C. glutamicum and UF-SSL. This research eliminates costly media additives and energy-intensive detoxification steps, paving the way for more efficient and sustainable industrial ethanol production.

13 sep. 202430 min read
Expression of the human molecular chaperone domain Bri2 BRICHOS on a gram per liter scale with an E. coli fed-batch culture

The goal of this research. conduced at Karolinska Institutet in Stockholm, Sweden, was to improve the productivity of human Bri2 BRICHOS domain production. The human Bri2 BRICHOS domain inhibits amyloid formation and toxicity and could be used as a therapeutic agent against amyloid diseases, such as alzheimers disease. 

13 sep. 202432 min read
Metabolic control analysis enabled the improvement of the L-cysteine production process with Escherichia coli

This research that was conducted at the Technical University of Munich, where scientists utilized an INFORS HT Techfors pilot bioreactor to evaluate and refine the expression of L-cysteine (amino acid widely used in pharmaceutical, food, feed, and cosmetic industries) synthases, achieving a productivity improvement of ~70%.

13 sep. 202435 min read
Non-inhibitory levels of oxygen during cultivation increase freeze-drying stress tolerance in Limosilactobacillus reuteri DSM 17938

This research was done by Nikhil Seshagiri Rao, Ph.D. and a team of scientists at Lund University in Sweden, published in the journal, Frontiers in Microbiology, where they utilized the INFORS HT Minifors bioreactor system with eve® bioprocess platform software to evaluate the effects of oxygen during cultivation on freeze-drying stress tolerance.

13 sep. 202426 min read
Development of a unique rapid test to detect antibodies directed against an extended RBD of SARS-CoV-2 spike protein

Researchers at University of Applied Sciences and Arts Northwestern Switzerland FHNW worked to develop a rapid test that measures patient immune protection from SARS-CoV-2, resulting from prior infection or vaccination. Their work utilized INFORS HT's Techfors-S pilot bioreactor.

13 sep. 202422 min read
Chemometric tool to monitor and predict cell viability in filamentous fungi bioprocesses using chromatogram fingerprints

Researchers at Technische Universität Wien sought to develop simplified and improved methods for monitoring and predicting cell viability in bioprocesses with complex expression systems, such as filamentous fungi. Their work utilized the INFORS HT Techfors-S pilot bioreactor.

13 sep. 202430 min read
Clostridium autoethanogenum alters cofactor synthesis, redox metabolism, and lysine-acetylation in response to elevated H2:CO feedstock ratios for enhancing carbon capture efficiency

A study conducted by LanzaTech, published in Biotechnology for Biofuels, explores how Clostridium autoethanogenum (an acetogenic bacterium) adapts to various hydrogen ratios in its feedstock. The focus of this study is to enhance carbon capture efficiency with a spotlight on CO₂ conversion. This research unveils the metabolic adaptations of C. autoethanogenum and paves the way for innovative bioengineering strategies to maximize CO₂ conversion in industrial applications.

13 sep. 202430 min read
Expression and characterization of recombinant IL-1Ra in Aspergillus oryzae as a system

In a new study, published on Springer Link, researchers produced a more stable and cost-effective interleukin-1 receptor antagonist (IL-1Ra) using Aspergillus oryzae. This alternative to E. coli-expressed IL-1Ra offers improved stability and bioactivity, making it a promising option for industrial-scale production. Explore the full findings and implications for therapeutic manufacturing.

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