Microbial production of 3-hydroxypropionic acid by acetic acid bacteria

Researchers at Université Paris-Saclay have developed a mathematical model that accurately predicts pH and metabolite concentrations during the microbial production of 3-hydroxypropionic acid using acetic acid bacteria. Using the INFORS HT Labfors bioreactor, the study focused on the bioconversion of 1,3-propanediol, taking into account the buffering capacity of the biological medium. Their model not only provided precise predictions of microbial growth and acid concentration but also serves as a critical tool for optimizing bioprocesses, particularly in scenarios with free pH dynamics. This work lays the foundation for future advancements in the production and in-situ extraction of organic acids.