Published: 13 set 2024(Updated: 25 nov 2024)
•6 min
•6 min read
•Sum Lai Lozada, Jose Alberto Gómez, Katherine Menéndez, Tania Gómez, Daidee Montes de Oca, Jose L. Durán, Olga Lidia Fernández, Yoel Perera, Gabriela Rivas, Tammy Boggiano-Ayo +Oxidative refolding by copper-catalyzed air oxidation consistently increases the homogeneity of a novel interleukin-2 mutein
Cell culture
In this study, researchers have optimized the purification of IL-2 no-alpha mutein using copper-catalyzed air oxidation. This process, using the INFORS HT Techfors pilot bioreactor, improves the homogeneity and biological activity of the IL-2 agonist, which shows promise in Phase I/II trials for cancer treatment.