Researchers at Adimab, LLC isolated 188 monoclonal antibodies against Crimean-Congo hemorrhagic fever virus (CCHFV) GP38 from human survivors. While non-neutralizing, these antibodies target 11 overlapping sites and demonstrate protective efficacy in rodent models. This study provides valuable insights into CCHFV viral glycoprotein and could aid the development of antibody therapeutics for this lethal virus.

Researchers from the Institute of Bioprocess Engineering and Pharmaceutical Technology at the University of Applied Sciences Mittelhessen have made strides in chemoorganotrophic electrofermentation using Cupriavidus necator. By experimenting with different redox mediators, they identified ferricyanide as a key player in enhancing anodic respiration. With the INFORS HT Multitron providing precise environmental control, the team achieved remarkable current densities, offering a promising solution to the challenges of oxygen-driven fermentation systems.

A plasmid DNA production process was performed comparing conventional Erlenmeyer flasks with LB medium and the Thomson’s Ultra Yield® system. E. coli cells were cultivated in both systems in the INFORS HT Multitron incubator shaker, bacterial growth was monitored, and the plasmids were purified at the end of cultivation. Subsequently, the quality of the isolated plasmids was analyzed by HPLC. The combination of the Ultra Yield® flasks with the enriched Plasmid+® medium and the AirOtop® enhanced seal led to higher cell densities and a 21-fold higher amount of plasmid than in Erlenmeyer shake flasks with LB medium.

The Multitron incubator shaker remains uniquely popular since its launch in 1991. The original concept was to offer maximum shake flask capacity whilst occupying minimum space within the laboratory. A number of other new features were launched alongside the Multitron, and since have become firm favourites with users. Some of the best loved capabilities of the Multitron are listed below.